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Can Prior Methamphetamine Exposure Change a Later Morphine Response? Why Age Mattered in a Rat Study
A 2012 experiment found reduced morphine antinociceptive potency after adult methamphetamine pretreatment, but not after periadolescent pretreatment. The tolerance results were harder to interpret and did not establish human opioid dosing.
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Does Amphetamine–Pseudoephedrine Cross-Tolerance in Rat Brain Mean the Drugs Have Equal Human Effects?
A 2008 experiment found cross-tolerance in a rat brain protein response, alongside much lower pseudoephedrine potency in a separate uptake assay. Neither result established equivalent human effects or relapse risk.
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Methamphetamine and Fly Development: Why a 24-Hour Laboratory Shift Is Not a Universal Time-of-Death Correction
Lucilia sericata developed differently on methamphetamine-spiked chicken liver at 28°C. Earlier emergence and altered size identify a potential confounder, without validating a fixed correction for human remains.
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Therapeutic Plasma Ranges and Autopsy Blood: What a 57,903-Case Drug Database Can Establish
A Finnish autopsy database compared drug-specific femoral-blood distributions with therapeutic plasma ranges. Its descriptive relationships were not paired measurements, lethal boundaries or individual redistribution corrections.
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Does Tolerance to Amphetamine’s Appetite Effects Depend on When Food Intake Is Measured?
A rat experiment separated immediate feeding suppression from reduced intake many hours later. Dose history changed the later pattern, while shifting baseline intake complicated the tolerance interpretation.
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Can Low Postmortem Blood Methanol Exclude a High Brain Concentration? Three Cases With Different Treatment Histories
In two treated methanol fatalities, brain concentrations remained much higher than autopsy blood results. A three-case report illustrates treatment, specimen and quantitation limits without establishing a universal brain-to-blood conversion.
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Buprenorphine in 55 of 2,369 Opioid Death Records: Detection Was Not a Causal Risk Estimate
A Marion County study found buprenorphine or norbuprenorphine in 2.3% of selected opioid-death records. The denominator, testing coverage and frequent co-detection limit causal and individual-risk interpretations.
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Bile Drug Screening After Death: Why 80% Agreement Missed the Amphetamine Problem
A 25-case bile study found useful screening agreement for several drug classes, but 80% amphetamine agreement concealed no positive concordance. Confirmation, matrix validation and reporting inconsistencies matter.
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What Can a Worm Swimming Assay Show About Amphetamine Tolerance?
Repeated amphetamine baths reduced a defined swimming response in C. elegans. The experiment supports a model for studying adaptation, while leaving internal drug exposure and the molecular mechanism unresolved.
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Does Liking Amphetamine Predict Liking Alcohol or THC? A Small Human Crossover Trial
A 24-person experiment did not find the expected general pattern of shared positive responses to amphetamine, alcohol and oral THC. Its preliminary subgroup findings require caution, and it did not test drug combinations.
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Can Methamphetamine Cardiovascular Responses Change Months After Use Stops? A Rhesus-Monkey Study
An anesthetized-monkey study found early cardiovascular tolerance and later enhancement of selected responses to methamphetamine challenge. The findings depended on endpoint, follow-up time and changing sample sizes.
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Does Delayed Plasma Amphetamine Explain Methamphetamine’s Drug Cue? A Three-Monkey Study
A controlled rhesus-monkey experiment separated a learned methamphetamine cue from plasma drug measurements. Delayed amphetamine formation did not explain the cue’s time course, and the endpoint was not a test of human impairment.
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Does Methamphetamine Sleep Tolerance Depend on the Pattern of Use? A Five-Monkey Experiment
A rhesus-monkey study compared continuous and interrupted methamphetamine self-administration. Apparent tolerance differed by schedule and sleep-related measure; actigraphy did not establish normal sleep physiology.
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Do Similar Amphetamine Metabolites Mean Equal Effects Across Species?
A historical comparison found similar amphetamine metabolite profiles in some species despite different doses and routes. Elimination patterns did not establish equal blood exposure, brain action or behavioral effects.
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Adding a New Nitazene to an Autopsy Assay: Why a Reference Standard and a Longer Run Were Not Full Validation
A nine-analyte method was extended to butonitazene and etodesnitazene using separate verification. Butonitazene also required a longer chromatographic run; the new targets did not inherit every original validation claim.
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The 1.5-Fold Methamphetamine Increase: What Three Paired Blood Cases Can—and Cannot—Establish
Three near-death whole-blood samples were compared with later iliac-artery blood. All postmortem results were higher, but the series did not validate a universal 1.5-fold correction.
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Does a Review of Stimulants and Stress Establish Amphetamine-Related Burnout Risk?
A 2026 synthesis discusses stimulants, stress and fatigue but reports no pooled burnout risk. Its clinical studies, mechanistic evidence and mixed-source tables require separate interpretation.
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Can the Dopamine Inverted-U Predict an Individual’s Amphetamine Response?
A 2014 mechanistic review explains why intermediate dopamine signaling can support working memory. Its conceptual curve does not locate an individual, identify an optimal amphetamine dose or establish a blood impairment threshold.
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Can Muscle Replace Blood for Postmortem MDMA Testing? Limits of a Rat Specimen-Selection Experiment
Biceps femoris muscle had relatively low, stable MDMA findings in a 720-rat experiment. That observation did not validate a human blood conversion or prove absence of postmortem change.
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Does Nonmedical Amphetamine Use Improve Grades? What a 2016 Review Could Establish
A historical review found that academic motives, lower GPA among people reporting misuse, and small laboratory cognitive effects answered different questions. None supplied a causal estimate of improved college grades.