Browse the latest forensic toxicology articles or search the collection.
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Did 6.25 mg of Extended-Release Mixed Amphetamine Salts Improve Childhood ADHD?
A historical four-week trial did not demonstrate efficacy at the tested low dose. Its null finding does not establish that every dose or formulation is ineffective.
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Can a Post Hoc Threshold Make Two Amphetamine Treatments Look Different?
A 50-child crossover reanalysis found a difference for “very much improved,” despite similar broader response percentages. The chosen threshold and post hoc design matter.
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Can Descriptive ADHD Item Scores Establish Age or Sex Differences in Amphetamine Response?
A historical reanalysis described symptom-item patterns without formal comparative testing. Numerical similarity or change is not a demonstrated interaction or equivalence result.
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Response Is Not Remission: Reading Adult Lisdexamfetamine Trial Percentages
Historical post hoc analyses used different definitions and populations for response, remission and maintenance. Their percentages cannot be treated as interchangeable recovery rates.
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Does Better Mathematics Performance in a Simulated Workplace Prove Better Job Performance?
A historical adult ADHD crossover trial improved a structured mathematics score. Its simulated workplace did not directly measure employment, job safety or productivity.
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Can a Medicine Beat Placebo at 13 Hours Without Improving on Its Own Predose Score?
A historical classroom crossover study found late placebo-adjusted effects, while late within-treatment changes from predose were nonsignificant. The reference comparison explains the apparent conflict.
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Did Lisdexamfetamine Reduce Methamphetamine Use? Why the Primary and Secondary Results Differ
A randomized trial found fewer use days across treatment but no significant benefit at its primary endpoint. The different time windows should not be collapsed into one efficacy claim.
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What Does a Lisdexamfetamine Withdrawal Trial Show About Maintaining Functional Benefits?
A historical withdrawal study tested continued treatment after an open-label period. Its selected responder population differs from people starting treatment for the first time.
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Do Better ADHD Symptom Scores Mean Better Quality of Life? A 317-Participant Analysis
A seven-week randomized trial measured parent-rated functioning separately from ADHD symptoms. Improvements varied across domains and did not establish superiority over another active medicine.
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Does a Two-Year Lisdexamfetamine Study Establish Long-Term Cognitive Safety?
A historical open-label study found no group-level deterioration on selected cognitive measures. Attrition, development and practice effects limit broader conclusions.
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Postmortem Urine and Bile Cannabinoids: Why Hydrolyzed Results Are Not Blood Levels
An 11-fatality study found useful cannabinoid detection in urine and bile, while inconsistent specimen distributions and hydrolysis limited quantitative interpretation.
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Can Muscle Replace Blood for Postmortem THC and CBD Interpretation?
A 39-case study detected cannabinoids in muscle but found wide, site-specific concentration ratios. Muscle results may support detection without reliably reconstructing blood levels.
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Can GHB Increase in Stored Postmortem Blood Without Known Ingestion?
An eight-month storage experiment and 20 individual blood specimens show why collection, fluoridation, temperature and analytical limits matter when interpreting postmortem GHB.
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Does More Decomposition Always Mean More Postmortem Ethanol?
An in vitro study found ethanol production concentrated in early-putrefactive tissue preparations. Advanced-stage results do not establish that advanced decomposition excludes prior formation.
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Can 1-Propanol Quantify Postmortem Ethanol Formation? Limits of a 2024 Model
A controlled putrefactive-blood experiment found a strong ethanol–1-propanol relationship. Its equation remains a proof of concept rather than a universal correction for autopsy BAC.
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Cocaethylene With No Detectable Ethanol: What an Emergency Study Can Actually Establish
Clinical findings show why self-reported drinking, current ethanol detection and cocaethylene are different evidence. The study did not validate a clock or postmortem marker.
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Can Clinical Cocaine Concentrations Define a Lethal Postmortem Cutoff?
An 81-patient emergency study did not establish a concentration-based severity rule. Its living-patient results cannot be converted into a fatal autopsy threshold.
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Can a Rat Experiment Supply a Human Postmortem THC Correction Factor?
Six rats showed different THC changes in heart and vena-cava blood. Route, sampling site, timing and species limit translation into human case calculations.
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The 49-Fold Chloroquine Ratio: Why Postmortem Blood and Earlier Serum Are Not a Pure Redistribution Experiment
A single chloroquine case illustrates how matrix, sampling time and tissue distribution complicate a dramatic postmortem-to-antemortem ratio.
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Does Femoral Blood Preserve the Antemortem Tricyclic Antidepressant Level?
Historical paired cases show why peripheral sampling improves interpretation without guaranteeing the living-person concentration. The pooled ratios are not individual corrections.