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Do Guanfacine and Lisdexamfetamine Cancel Each Other’s Cardiovascular Effects?
A historical crossover study found similar active amphetamine exposure with and without guanfacine. That result did not establish that the two medicines cancel each other’s effects on pulse or blood pressure.
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The ARTEMIS Methamphetamine Trial: Lower HIV Viral Load Did Not Mean Every Stimulant Outcome Improved
A 110-man randomized trial found lower HIV viral load with a positive-affect intervention added to contingency management. Urine stimulant outcomes, craving and immune-cell counts did not all show corresponding significant differences.
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Lisdexamfetamine and CYP Probe Drugs: A Lower Omeprazole Peak Did Not Identify an Enzyme Mechanism
A 30-adult crossover experiment used four probe drugs to examine metabolic interactions with lisdexamfetamine. Omeprazole peak concentration and total exposure moved differently, leaving an absorption-versus-enzyme explanation unresolved.
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Methamphetamine Testing in Children: Why a Negative Urine Result Did Not Settle a Three-Matrix Comparison
A historical study compared hair, urine and oral fluid from children referred after suspected household exposure. Different detection windows, analytical limits and available specimens prevented a negative urine result from excluding exposure or identifying its route.
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Amphetamine Exposure After Bariatric Surgery: Why 409 Samples Represented Only Four Lisdexamfetamine Patients
A small longitudinal case series found increased serum dexamphetamine exposure after bariatric surgery in four people taking lisdexamfetamine. Dose adjustment, surgical type and the absence of a nonsurgical weight-loss control limit the inference.
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Lisdexamfetamine With Venlafaxine: Similar Amphetamine Exposure Did Not Mean Similar Pulse and Blood Pressure
A historical healthy-adult study found similar d-amphetamine exposure during lisdexamfetamine–venlafaxine coadministration, alongside larger observed pulse and blood-pressure increases. Pharmacokinetic equivalence did not establish equivalent physiological effects.
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Lisdexamfetamine With Orange Juice or Yogurt: Lower Prodrug Exposure Did Not Mean Less Active Amphetamine
A 30-adult crossover study found that active d-amphetamine met prespecified bioequivalence criteria across the tested administration methods, even when intact lisdexamfetamine did not. The analyte and comparison criterion change the interpretation.
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Self-Reported Methamphetamine Use: Why 327 Visits Did Not Mean 327 Independent Participants
A validation analysis compared recent self-reported methamphetamine use with urine screening across 327 visits from 90 adults. Agreement depended on the recall window and study setting; discordance was not a validated test of dishonesty.
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Varenicline in a Methamphetamine Trial: Reduced Cigarette Smoking Was Not Improved Methamphetamine Abstinence
A 52-participant randomized trial found no significant methamphetamine-abstinence benefit from varenicline at 1 mg twice daily. Cigarette smoking declined, illustrating why an effect on one substance cannot substitute for the prespecified treatment outcome.
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Methamphetamine and Ischemic Stroke: Less Atrial Fibrillation Did Not Exclude a Cardiac Embolic Pattern
A 938-patient ischemic-stroke cohort found more cardiomyopathy but less recorded atrial fibrillation in the methamphetamine group. Its findings concern selected stroke patients and a combined cardiac-exposure classification, rather than the probability of stroke after drug use.
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Methamphetamine in Health Records: Why 814 Chart Reviews Did Not Validate a Perfect Detection Algorithm
A 2025 study compared eight groups of health-record markers with chart review. Predictive values varied widely, and even a group with a value of 1.00 did not establish universal sensitivity or a gold standard for exposure.
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Lisdexamfetamine in Renal Impairment: Active Amphetamine Exposure and Prodrug Assay Interference Were Different Findings
A 40-adult single-dose study found prolonged d-amphetamine exposure with increasing renal impairment. Interpretation of lisdexamfetamine itself was complicated by an unexpected plasma matrix effect in the dialysis group.
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Methamphetamine and Suspected Thyroid Storm: Why a Clinical Score Did Not Identify the Trigger
A historical case combined untreated hyperthyroidism, reported first-time methamphetamine use and a Burch–Wartofsky score of 35. The report documents suspected thyroid storm and a complicated treatment course, rather than proving a drug-specific trigger.
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Methamphetamine, Water Intake and Rhabdomyolysis: Why One Case Could Not Isolate a Single Cause
A 2022 case combined reported methamphetamine inhalation, rapid water intake, thiazide exposure, severe hyponatraemia and seizures before marked muscle injury. The sequence is informative; it cannot apportion causation between the overlapping factors.
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Methamphetamine and HIV Viral Suppression: A Null Adherence-Mediation Result Did Not Prove a Direct Drug Mechanism
A 2020 cohort associated recent methamphetamine use with unsuppressed HIV viral load. Its self-reported adherence measure did not explain the association statistically, but that finding could not establish a direct pharmacological mechanism.
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Severe Maternal Morbidity and Methamphetamine Codes: What a 4.8-Million-Pregnancy Cohort Actually Measured
A California record-linkage study found more severe maternal morbidity among pregnancies with psychostimulant-use codes. The composite outcome, absolute frequencies and coding-based exposure definition prevent an adjusted risk ratio from becoming an individual causal prediction.
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Methamphetamine Heart-Failure Follow-Up: A Negative Urine Test Was Not a Year of Verified Abstinence
A small retrospective cohort associated cessation status with improved ejection fraction and fewer heart-failure admissions. Its definition of cessation, changing denominators and preserved-EF null findings are essential to interpreting the result.
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Corneal Ulcers and Methamphetamine: Why a Class Screen and Missing Cultures Leave Causal Questions Open
A 2025 case documented bilateral corneal ulcers, an amphetamine-positive screen and uncontrolled diabetes. Cultures were declined. The observations support a careful differential assessment, rather than a drug-specific causal diagnosis from appearance or screening alone.
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Urine pH and Amphetamine Plasma Exposure: Which Model Predictions Had Human Verification?
A 2020 pharmacokinetic model predicted substantial changes in amphetamine exposure with urine pH. Human verification differed by specimen, endpoint and pH condition; the alkaline-urine plasma scenario lacked clinical verification.
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How Blood Cells Activate Lisdexamfetamine: Locating Hydrolysis Did Not Identify the Exact Enzyme
A pooled-donor laboratory experiment localized lisdexamfetamine conversion mainly to a blood-cell cytosolic fraction. Inhibitor findings suggested aminopeptidase-like activity, but purified aminopeptidase B did not release detectable d-amphetamine.